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Hematological Malignancies

Sunday, August 12th 2012. | Blood System, Disease

Hematological Malignancies Definition

Hematologic malignancies are rare diseases, increases with age (for multiple myeloma) who received great progress  therapeutic.

The survival of these conditions including those deemed incurable and quality of life of people with the disease have been improved in recent years.

The age of onset is variable but these diseases are being increasingly often in patients aged over 65, such as myeloma or chronic lymphocytic leukemia (CLL).

Hematological Malignancies Sign

Various hematological malignancies may occur in the elderly.The main ones are:

  • Non-Hodgkin’s lymphoma,
  • Chronic lymphocytic leukemia,
  • Multiple Myeloma
  • Hodgkin’s disease and myeloproliferative disorders.
Hematological Malignancies diagram

Hematological Malignancies diagram (img thanks to hindawi.com)

These blood diseases suspected to be general symptoms such as unexplained fatigue lasting, persistent low grade fever, the existence of nodes or unusual pain resistant to common therapies, or the occurrence of atypical infections or unexplained fractures are also suggestive signs up towards further investigation and diagnosis.

Other signs are also suggestive of malignancy: night sweats, significant weight loss without dieting, difficulty in breathing. It’s occurring in a context again to direct the diagnosis.

Hematological Malignancies

Hematological Malignancies Patient (img thanks to ki.se)

Hematological Malignancies Evolution

The discovery of a hematologic malignancy requires a staging of the disease

This assessment must evaluate the functionality of prinicipaux organs may be affected such as the liver, and heart Renis). it must also achieve a balance of general condition for the existence of other diseases (diabetes, heart failure, …), nutritional disorders, or disorders of higher functions (memory, vigilance, …). There may be depression.

Treatment protocols are discussed by multidisciplinary teams who decide therapeutic procedures based on the diagnosis, staging and medical and social context.

According to the molecules used, care during chemotherapy treatments will be implemented to prevent the occurrence of such infections or cytopenia (severe drop in certain blood cells, such profound anemia).

Hematological Malignancies Risk Factor

Exposure to toxic chemicals (fertilizers, benzene, hydrocarbons, …), previous radiotherapy or chemotherapy for cancer or accidental exposure to radiation are particularly high risk of developing a malignancy, including a leukemia.

The existence of unusual clinical manifestations (bleeding, pallor, …), persistent signs of fever or scraping should not be trivialized (“it is related to age), or made into the background compared to existing conditions: age and present unusual symptoms, you should know can search a hematological malignancy.


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